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The oxidative decarboxylation of pyruvic acid
Formation of acetylCoA from pyruvic acid

Pyruvic acid is the main product of glycolysis. Its oxidative decarboxylation to acetylcoenzyme A prepares its entry into the citric acid cycle (Krebs cycle).

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Steps

1 Pyruvate 2 Thiaminepyrophosphate (TPP) 3 Acyl-TPP 4 Lipoylamide 5 Amide of acyllipoate 6 Dihydrolipoylamide 7 Coenzyme A 8 Acetylcoenzyme A

References

For glycolysis see →                 here For details on the role of NAD + see →               here For details on the role of the FAD see →               here For the Krebs cycle see →           here