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# Coenzyme A ($CoASH$): Mail Service of the Living

The $CoASH$ can be compared to a courier truck. For example, it can load acetyl groups and transmit them.

Its suppliers of acetyl are either pyruvate (from carbohydrates) or amino acids (from proteins) ( 2 ) or fatty acids (from lipids) ( 3 ). Its receiver is either the Krebs cycle, an energy provider ( 4 ), or systems that remake new amino acids ( 5 ) or fatty acids ( 6 ):

# The $CoASH$ structure

1 : adenine 2 : ribosephosphate 3 : diphosphate group 4 : amide group of pantothenic acid 5 : group β-mercaptoethylamine

# The $CoASH$ role

The $CoASC=O R$ is therefore a thioester The most important case is the formation of acetylCoA ($R = CH_3$), but other acyl groups can also be involved!